Neurobiology of Disease Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege
نویسندگان
چکیده
Jens Neumann,1 Steven Sauerzweig,1 Raik Rönicke,1 Frank Gunzer,3 Klaus Dinkel,1 Oliver Ullrich,2,4 Matthias Gunzer,2,5* and Klaus G. Reymann1,6* 1Leibniz Institute for Neurobiology, Project Group Neuropharmacology, and 2Institute of Immunology, Otto von Guericke University Magdeburg, 39118 Magdeburg, Germany, 3German University in Cairo, 11771 Cairo, Egypt, 4Institute of Anatomy, Faculty of Medicine, University Zurich, CH-8057 Zurich, Switzerland, 5Helmholtz Centre for Infection Research, Junior Research Group Immunodynamics, 38124 Braunschweig, Germany, and 6Institute for Applied Neuroscience (Institute für Angewandte Neurowissenschaften FAN gGmbH), 39120 Magdeburg, Germany
منابع مشابه
Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege.
Microglial cells maintain the immunological integrity of the healthy brain and can exert protection from traumatic injury. During ischemic tissue damage such as stroke, peripheral immune cells acutely infiltrate the brain and may exacerbate neurodegeneration. Whether and how microglia can protect from this insult is unknown. Polymorphonuclear neutrophils (PMNs) are a prominent immunologic infil...
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